Author: IEEE Reviews in Biomedical Engineering - new TOC

Provides a listing of current staff, committee members and society officers.

Presents the front cover for this issue of the publication.

Low-resource clinical settings are plagued by low physician-to-patient ratios and a shortage of high-quality medical expertise and infrastructure. Together, these phenomena lead to over-burdened healthcare systems that under-serve the needs of the community. Alleviating this burden can be undertaken by the introduction of clinical decision support systems (CDSSs); systems that support stakeholders (ranging from physicians to patients) within the clinical setting in their day-to-day activities. Such systems, which have proven to be effective in the developed world, remain to be under-explored in low-resource settings. This review attempts to summarize the research focused on clinical decision support systems that either target stakeholders within low-resource clinical settings or diseases commonly found in such environments. When categorizing our findings according to disease applications, we find that CDSSs are predominantly focused on dealing with bacterial infections and maternal care, do not leverage deep learning, and have not been evaluated prospectively. Together, these highlight the need for increased research in this domain in order to impact a diverse set of medical conditions and ultimately improve patient outcomes.

Assessing blood flow, respiration patterns, and body composition with wearable and noninvasive bio-impedance (BioZ) sensors has distinctive advantages over the conventional clinical practice. The merits of BioZ sensors derive from having long-term monitoring capability and improved user friendliness. These open up the way to build medical grade wearable devices for chronic conditions. Low power, high precision BioZ sensor interface IC is the heart of such devices, it also determines the signal integrity of the overall system. Nevertheless, electrical design challenges from both circuit and system perspective still need to be addressed. This paper reviews the pioneering BioZ interface ICs and systems, and proposes major electrical specifications for wearable BioZ sensors. System design methodologies and circuit optimization techniques are summarized as guidelines to develop the next generation BioZ interface electronics.

COVID-19 is a life threatening disease which has a enormous global impact. As the cause of the disease is a novel coronavirus whose gene information is unknown, drugs and vaccines are yet to be found. For the present situation, disease spread analysis and prediction with the help of mathematical and data driven model will be of great help to initiate prevention and control action, namely lockdown and qurantine. There are various mathematical and machine-learning models proposed for analyzing the spread and prediction. Each model has its own limitations and advantages for a particluar scenario. This article reviews the state-of-the art mathematical models for COVID-19, including compartment models, statistical models and machine learning models to provide more insight, so that an appropriate model can be well adopted for the disease spread analysis. Furthermore, accurate diagnose of COVID-19 is another essential process to identify the infected person and control further spreading. As the spreading is fast, there is a need for quick auotomated diagnosis mechanism to handle large population. Deep-learning and machine-learning based diagnostic mechanism will be more appropriate for this purpose. In this aspect, a comprehensive review on the deep learning models for the diagnosis of the disease is also provided in this article.

Synchronization of human vital signs, namely the cardiac cycle and respiratory excursions, is necessary during magnetic resonance imaging of the cardiovascular system and the abdominal cavity to achieve optimal image quality with minimized artifacts. This review summarizes techniques currently available in clinical practice, as well as methods under development, outlines the benefits and disadvantages of each approach, and offers some unique solutions for consideration.

The accuracy of the magnetic resonance (MR) image diagnosis depends on the quality of the image, which degrades mainly due to noise and artifacts. The noise is introduced because of erroneous imaging environment or distortion in the transmission system. Therefore, denoising methods play an important role in enhancing the image quality. However, a tradeoff between denoising and preserving the structural details is required. Most of the existing surveys are conducted on a specific MR image modality or on limited denoising schemes. In this context, a comprehensive review on different MR image denoising techniques is inevitable. This survey suggests a new direction in categorizing the MR image denoising techniques. The categorization of the different image models used in medical image processing serves as the basis of our classification. This study includes recent improvements on deep learning-based denoising methods alongwith important traditional MR image denoising methods. The major challenges and their scope of improvement are also discussed. Further, many more evaluation indices are considered for a fair comparison. An elaborate discussion on selecting appropriate method and evaluation metric as per the kind of data is presented. This study may encourage researchers for further work in this domain.

Hands are vital in a wide range of fundamental daily activities, and neurological diseases that impede hand function can significantly affect quality of life. Wearable hand gesture interfaces hold promise to restore and assist hand function and to enhance human-human and human-computer communication. The purpose of this review is to synthesize current novel sensing interfaces and algorithms for hand gesture recognition, and the scope of applications covers rehabilitation, prosthesis control, exoskeletons for augmentation, sign language recognition, human-computer interaction, and user authentication. Results showed that electrical, mechanical, acoustical/vibratory, and optical sensing were the primary input modalities in gesture recognition interfaces. Two categories of algorithms were identified: 1) classification algorithms for predefined, fixed hand poses and 2) regression algorithms for continuous finger and wrist joint angles. Conventional machine learning algorithms, including linear discriminant analysis, support vector machines, random forests, and non-negative matrix factorization, have been widely used for a variety of gesture recognition applications, and deep learning algorithms have more recently been applied to further facilitate the complex relationship between sensor signals and multi-articulated hand postures. Future research should focus on increasing recognition accuracy with larger hand gesture datasets, improving reliability and robustness for daily use outside of the laboratory, and developing softer, less obtrusive interfaces.

Cardiovascular disease (CVD) is a group of heart and vasculature conditions which are the leading form of mortality worldwide. Blood vessels can become narrowed, restricting blood flow, and drive the majority of hearts attacks and strokes. Reactive surgical interventions are frequently required; including percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). Despite successful opening of vessels and restoration of blood flow, often in-stent restenosis (ISR) and graft failure can still occur, resulting in subsequent patient morbidity and mortality. A new generation of cardiovascular implants that have sensors and real-time monitoring capabilities are being developed to combat ISR and graft failure. Self-reporting stent/graft technology could enable precision medicine-based and predictive healthcare by detecting the earliest features of disease, even before symptoms occur. Bringing an implantable medical device with wireless electronic sensing capabilities to market is complex and often obstructive undertaking. This critical review analyses the obstacles that need to be overcome for self-reporting stents/grafts to be developed and provide a precision-medicine based healthcare for cardiovascular patients. Here we assess the latest research and technological advancement in the field, the current devices; including smart cardiovascular implantable biosensors and associated wireless data and power transfer solutions. We include an evaluation of devices that have reached clinical trials and the market potential for their end-user implementation.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic since early 2020. The coronavirus disease 2019 (COVID-19) has already caused more than three million deaths worldwide and affected people's physical and mental health. COVID-19 patients with mild symptoms are generally required to self-isolate and monitor for symptoms at least for 14 days in the case the disease turns towards severe complications. In this work, we overviewed the impact of COVID-19 on the patients' general health with a focus on their cardiovascular, respiratory and mental health, and investigated several existing patient monitoring systems. We addressed the limitations of these systems and proposed a wearable telehealth solution for monitoring a set of physiological parameters that are critical for COVID-19 patients such as body temperature, heart rate, heart rate variability, blood oxygen saturation, respiratory rate, blood pressure, and cough. This physiological information can be further combined to potentially estimate the lung function using artificial intelligence (AI) and sensor fusion techniques. The prototype, which includes the hardware and a smartphone app, showed promising results with performance comparable to or better than similar commercial devices, thus potentially making the proposed system an ideal wearable solution for long-term monitoring of COVID-19 patients and other chronic diseases.